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8-pCPT-cGMP-AM

8-pCPT-cGMP-AM (8- (4-Chlorophenylthio) -cGMP-AM) is a highly membrane permeable prodrug of the PKG agonist 8-pCPT-cGMP, which increases the membrane permeability of cGMP and is converted to its active form by esterase hydrolysis within the cell, thereby activating PKG. 8-pCPT-cGMP-AM can be used to explore the role of cGMP signaling in neural plasticity and memory formation[1].

Product Specifications

CAS Number

[272445-72-4]

Product Name Alternative

8- (4-Chlorophenylthio) -cGMP-AM

UNSPSC

12352005

Target

PKG

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/8-pcpt-cgmp-am.html

Smiles

O[C@@H]1[C@H](OP2(OCOC(C)=O)=O)[C@@H](CO2)O[C@H]1N3C(SC4=CC=C(Cl)C=C4)=NC5=C3N=C(N)NC5=O

Molecular Formula

C19H19ClN5O9PS

Molecular Weight

559.87

References & Citations

[1]Butt E. cGMP-dependent protein kinase modulators[J]. cGMP: Generators, Effectors and Therapeutic Implications, 2009: 409-421.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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