8-pCPT-cGMP-AM
8-pCPT-cGMP-AM (8- (4-Chlorophenylthio) -cGMP-AM) is a highly membrane permeable prodrug of the PKG agonist 8-pCPT-cGMP, which increases the membrane permeability of cGMP and is converted to its active form by esterase hydrolysis within the cell, thereby activating PKG. 8-pCPT-cGMP-AM can be used to explore the role of cGMP signaling in neural plasticity and memory formation[1].
Product Specifications
CAS Number
[272445-72-4]
Product Name Alternative
8- (4-Chlorophenylthio) -cGMP-AM
UNSPSC
12352005
Target
PKG
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/8-pcpt-cgmp-am.html
Smiles
O[C@@H]1[C@H](OP2(OCOC(C)=O)=O)[C@@H](CO2)O[C@H]1N3C(SC4=CC=C(Cl)C=C4)=NC5=C3N=C(N)NC5=O
Molecular Formula
C19H19ClN5O9PS
Molecular Weight
559.87
References & Citations
[1]Butt E. cGMP-dependent protein kinase modulators[J]. cGMP: Generators, Effectors and Therapeutic Implications, 2009: 409-421.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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