RWJ-58643
RWJ-58643 is a β-trypsin inhibitor that suppresses allergic inflammation. RWJ-58643 (100 mg) significantly reduced nasal allergy symptoms, eosinophil infiltration, and IL-5 levels at low doses. RWJ-58643 resulted in late eosinophilia and elevated IL-5 levels at high doses (300 mg and 600 mg) . RWJ-58643 modulates allergic responses by inhibiting the release of β-trypsin from mast cells[1].
Product Specifications
CAS Number
287183-00-0
UNSPSC
12352005
Target
Ser/Thr Protease
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/rwj-58643.html
Smiles
O=C([C@H]1N(C(C)=O)C[C@H](O)C1)NC(C(C2=NC3=CC=CC=C3S2)=O)CCCNC(N)=N
Molecular Formula
C20H26N6O4S
Molecular Weight
446.52
References & Citations
[1]Effects of a reversible b-tryptase and trypsin inhibitor (RWJ-58643) on nasal allergic responses
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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