ARN726
ARN726 is a potent NAAA (N-acylethanolamine acid amidase) inhibitor with an IC50 of 0.073 µM. ARN726 decreases alcohol self-administration in a dose-dependent manner[1][2].
Product Specifications
CAS Number
1628343-77-0
UNSPSC
12352005
Target
Others
Type
Reference compound
Related Pathways
Others
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/arn726.html
Purity
95.00
Solubility
DMSO : 36.67 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(OCCCCC1CCCCC1)N[C@@H]2C(NC2)=O
Molecular Formula
C14H24N2O3
Molecular Weight
268.35
References & Citations
[1]Fotio Y, et al. N-acylethanolamine acid amidase (NAAA) inhibition decreases the motivation for alcohol in Marchigian Sardinian alcohol-preferring rats. Psychopharmacology (Berl) . 2021 Jan;238 (1) :249-258.|[2]Petracca R, et al. Novel activity-based probes for N-acylethanolamine acid amidase. Chem Commun (Camb) . 2017 Aug 22;53 (86) :11810-11813.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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