Plantainoside D

Plantainoside D, a phenylethanoid glycosides, is a IKK-β inhibitor with diverse biological activities. Plantainoside D shows inhibitory activity of angiotensin-converting enzyme (ACE) with an IC50 of 2.17 mM. Plantainoside D significantly reduces the release of glutamate from nerve terminals in the cerebral cortex of rats by inhibiting the voltage-dependent calcium channel (VDCCs) and protein kinase C (PKC) signaling cascade. Plantainoside D significantly alleviates cell apoptosis by inhibiting the generation of ROS and the activation of NF-κB. Plantainoside D significantly improves acute lung injury (ALI) induced by sepsis by regulating the Sirt3/NLRP3 signaling pathway. Plantainoside D can be used for the study of neuroprotection, antioxidant, anti-inflammation, antihypertension[1][2][3][4][5][6].

Product Specifications

CAS Number

[147331-98-4]

UNSPSC

12352005

Target

Angiotensin-converting Enzyme (ACE) ; Apoptosis; Calcium Channel; IKK; NF-κB; NOD-like Receptor (NLR) ; PKC; Reactive Oxygen Species (ROS) ; Sirtuin

Type

Natural Products

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB; TGF-beta/Smad

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/plantainoside-d.html

Concentration

10mM

Purity

99.92

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O[C@H]([C@H]([C@@H]([C@@H](COC(/C=C/C1=CC=C(O)C(O)=C1)=O)O2)O)O[C@H]3[C@@H]([C@H]([C@@H]([C@@H](CO)O3)O)O)O)[C@@H]2OCCC4=CC=C(O)C(O)=C4

Molecular Formula

C29H36O16

Molecular Weight

640.59

References & Citations

[1]Geng F, Yang L, Chou G, Wang Z. Bioguided isolation of angiotensin-converting enzyme inhibitors from the seeds of Plantago asiatica L. Phytother Res. 2010;24 (7) :1088-1094.|[2]Zhou P, Hua F, Wang X, Huang JL. Therapeutic potential of IKK-β inhibitors from natural phenolics for inflammation in cardiovascular diseases. Inflammopharmacology. 2020;28 (1) :19-37. |[3]Chiu KM, et al. Plantainoside D Reduces Depolarization-Evoked Glutamate Release from Rat Cerebral Cortical Synaptosomes. Molecules. 2023 Jan 30;28 (3) :1313. |[4]Wang J, et al. Sirt3 regulates NLRP3 and participates in the effects of plantainoside D on acute lung injury sepsis. Aging (Albany NY) . 2023 Apr 5;15 (14) :6710-6720.|[5]Kim DS, et al. Plantainoside D protects adriamycin-induced apoptosis in H9c2 cardiac muscle cells via the inhibition of ROS generation and NF-kappaB activation. Life Sci. 2007 Jan 2;80 (4) :314-23.|[6]Zhou J, et al. Human liver microsomes study on the inhibitory effect of plantainoside D on the activity of cytochrome P450 activity. BMC Complement Med Ther. 2022 Jul 23;22 (1) :197.