GSPT1 degrader-10
GSPT1 degrader-10 (compound A) is a cereblon-based molecular glue degrader of GSPT1 with more than 95% degradation. GSPT1 degrader-8 inhibits cell viability in HL-60 cells with an IC50 of 10 nM[1].
Product Specifications
CAS Number
[3024909-61-0]
UNSPSC
12352005
Target
Molecular Glues
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-gspt1-degrader-2.html
Smiles
O=C1NC(C(CC1)N2C(C3=CC=C(N4CCC(CC4)CN5C(N(CCC5)C6=CC(C7=C(Cl)C8=C(NC=C8CC)N=C7)=CC=C6)=O)C=C3C2=O)=O)=O
Molecular Formula
C38H38ClN7O5
Molecular Weight
708.21
References & Citations
[1]Lichao FANG, et al. Gspt1 degraders, compositions comprising the degrader, and methods of using the same. French, WO2024073871A1. 2024-04-11
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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