GSPT1 degrader-10

GSPT1 degrader-10 (compound A) is a cereblon-based molecular glue degrader of GSPT1 with more than 95% degradation. GSPT1 degrader-8 inhibits cell viability in HL-60 cells with an IC50 of 10 nM[1].

Product Specifications

CAS Number

[3024909-61-0]

UNSPSC

12352005

Target

Molecular Glues

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-gspt1-degrader-2.html

Smiles

O=C1NC(C(CC1)N2C(C3=CC=C(N4CCC(CC4)CN5C(N(CCC5)C6=CC(C7=C(Cl)C8=C(NC=C8CC)N=C7)=CC=C6)=O)C=C3C2=O)=O)=O

Molecular Formula

C38H38ClN7O5

Molecular Weight

708.21

References & Citations

[1]Lichao FANG, et al. Gspt1 degraders, compositions comprising the degrader, and methods of using the same. French, WO2024073871A1. 2024-04-11

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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