1,6-Dihydro-4,7-epoxy-1-methoxy-3,4-methylenedioxy-6-oxo-3,8-lignan

1,6-Dihydro-4,7-epoxy-1-methoxy-3,4-methylenedioxy-6-oxo-3,8-lignan, a lignan derivative from the ethyl acetate soluble fraction of twigs of Magnolia denudate (Magnoliaceae), exhibits anti-platelet-activating factor (PAF) activity. PAF is a potent lipid mediator in inflammation and asthma[1].

Product Specifications

CAS Number

[57430-03-2]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Platelet-activating Factor Receptor (PAFR)

Type

Natural Products

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/1-6-dihydro-4-7-epoxy-1-methoxy-3-4-methylenedioxy-6-oxo-3-8-lignan.html

Solubility

10 mM in DMSO

Smiles

C[C@H]1C(C(O[C@]1([H])C2=CC=C(OCO3)C3=C2)=C4)=C[C@](CC=C)(OC)C4=O

Molecular Formula

C20H20O5

Molecular Weight

340.37

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]M Kuroyanagi, et al. Bicyclo[3.2.1]octane and 6-oxabicyclo[3.2.2]nonane type neolignans from Magnolia denudate. Chem Pharm Bull (Tokyo) . 2000 Jun;48 (6) :832-7.