S-Thanatin

S-Thanatin is an insect antimicrobial peptide with potent broad-spectrum antibacterial activity. S-Thanatin can inhibit the activity of Gram-negative bacteria, Gram-positive bacteria, and fungi, without cytotoxicity. The antibacterial activity of S-Thanatin is not affected by PH value, but monovalent cations (Na+/K+) can reduce its antibacterial activity against Gram-negative bacteria in a dose-dependent manner[1].

Product Specifications

CAS Number

1027105-06-1

UNSPSC

12352209

Target

Bacterial; Fungal

Type

Peptides

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/s-thanatin.html

Solubility

10 mM in DMSO

Smiles

C([C@@H](NC([C@@H](NC([C@@H](NC(CN)=O)CO)=O)CCCCN)=O)CCCCN)(=O)N1[C@H](C(N[C@H](C(=O)N2[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC3=CC=C(O)C=C3)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCSC)C(O)=O)=O)CCCNC(=N)N)=O)CCC(N)=O)=O)CS)=O)CCCCN)=O)=O)CO)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CC(N)=O)=O)CS)=O)=O)[C@H](CC)C)=O)[C@H](CC)C)=O)CCC2)[C@@H](C)C)=O)CCC1

Molecular Formula

C102H177N35O27S3

Molecular Weight

2421.91

References & Citations

[1]Wu G, et al. Effects of cations and pH on antimicrobial activity of thanatin and s-thanatin against Escherichia coli ATCC25922 and B. subtilis ATCC 21332[J]. Nature Precedings, 2008: 1-1.