OTSSP167 (hydrochloride)
Product Specifications
UNSPSC Description
OTSSP167 (OTS167) hydrochloride is a highly potent and ATP-competitive MELK inhibitor with IC50 value of 0.41 nM.
Target Antigen
MELK
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/OTSSP167-hydrochloride.html
Solubility
DMSO : 33.33 mg/mL (ultrasonic)|H2O : 7.14 mg/mL (ultrasonic)
Smiles
ClC1=CC(C2=CC=C(N=CC(C(C)=O)=C3N[C@H]4CC[C@H](CN(C)C)CC4)C3=N2)=CC(Cl)=C1O.[H]Cl
Molecular Weight
523.88
References & Citations
[1]Chung S, Suzuki H, Miyamoto T, et al. Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer. Oncotarget. 2012 Dec 21.|[2]Ji W, et al. OTSSP167 Abrogates Mitotic Checkpoint through Inhibiting Multiple Mitotic Kinases. PLoS One. 2016 Apr 15;11(4):e0153518.|[3]Cho YS, et al. The crystal structure of MPK38 in complex with OTSSP167, an orally administrative MELK selective inhibitor. Biochem Biophys Res Commun. 2014 Apr 25;447(1):7-11.|[4]Jurmeister S, et al. Identification of potential therapeutic targets in prostate cancer through a cross-species approach. EMBO Mol Med. 2018 Feb 5. pii: e8274.|[5]Meel MH, et al. MELK inhibition in Diffuse Intrinsic Pontine Glioma. Clin Cancer Res. 2018 Jul 30. pii: clincanres.0924.2018.Clin Cancer Res. 2018 Nov 15;24(22):5645-5657. |Elife. 2017 Mar 24;6:e24179.|Elife. 2018 Feb 8;7:e32838. |EMBO Mol Med. 2018 Mar;10(3). pii: e8274.|Free Radic Biol Med. 2021 Jun 15;S0891-5849(21)00377-4.|Gynecol Oncol. 2017 Apr;145(1):159-166.|Harvard Medical School LINCS LIBRARY|Nat Cancer. 2024 Jul 11.|Neuro Oncol. 2020 Jan 11;22(1):58-69. |Biochem Biophys Res Commun. 2014 Apr 25;447(1):7-11. |Blood Cancer J. 2019 Nov 18;9(12):87.|Int J Oncol. 2022 Jul;61(1):89.|Mol Cancer. 2014 May 4;13:100.|Oncotarget. 2016 Feb 2;7(5):6266-80. |Oncotarget. 2017 Dec 20;9(2):2591-2602. |Patent. US20160291017A1.|PLoS One. 2017 Feb 24;12(2):e0172832. |Sci Rep. 2017 Feb 14;7:42502.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-15512A/OTSSP167-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-15512A/OTSSP167-hydrochloride-SDS-MedChemExpress.pdf
Clinical Information
Phase 2
CAS Number
1431698-10-0
Available Sizes
Curated Selection
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