BIM5078
BIM5078 is a hepatocyte nuclear factor 4α (HNF4α) antagonist that can inhibit the expression of known HNF4α target genes. BIM5078 represses insulin promoter activity through HNF4α antagonism. BIM5078 can be used for the research of cancer and diabetes[1].
Product Specifications
CAS Number
[337506-43-1]
UNSPSC
12352005
Hazard Statement
H301
Target
Nuclear Hormone Receptor 4A/NR4A
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/bim5078.html
Solubility
10 mM in DMSO
Smiles
[O-][N+](C1=CC=C(C(S(=O)(N2C3=C(N=C2C)C=CC=C3)=O)=C1)Cl)=O
Molecular Formula
C14H10ClN3O4S
Molecular Weight
351.76
Precautions
P264-P270-P330-P405-P501
References & Citations
[1]Kiselyuk A, et al. HNF4α antagonists discovered by a high-throughput screen for modulators of the human insulin promoter. Chem Biol. 2012 Jul 27;19 (7) :806-18.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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