NMDAR2B Recombinant Rabbit Monoclonal Antibody [PSH05-46]
Glutamate [NMDA] receptor subunit epsilon-2, also known as N-methyl D-aspartate receptor subtype 2B (NMDAR2B or NR2B), is a protein that in humans is encoded by the GRIN2B gene. NR2B has been associated with age- and visual-experience-dependent plasticity in the neocortex of rats, where an increased NR2B/NR2A ratio correlates directly with the stronger excitatory LTP in young animals. This is thought to contribute to experience-dependent refinement of developing cortical circuits. Engineered to overexpress GRIN2B in their brains, mice and rats exhibit improved mental function. The "Doogie" mouse performed twice as well on one learning test.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
GRIN2B, NMDAR2B
Swiss Prot
Q13224 Human, Q01097 Mouse, Q00960 Rat
Cellular Locus
Cell membrane, Postsynaptic cell membrane, Late endosome, Lysosome, Cytoplasm, cytoskeleton.
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Recombinant protein within human NMDAR2B aa 27-450 / 1,484.
Isotype
IgG
Clone
PSH05-46
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IHC-P, IHC-Fr
Positive Control
Concentration
1 mg/mL
Dilution
WB: 1:2,000 ;IHC-P: 1:2,000-1:8,000 ;IHC-Fr: 1:500
Purity
Protein A affinity purified.
Form
Liquid
Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 166 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
Frequently Asked Questions
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