1,10-Phenanthroline

1,10-Phenanthroline is a metal chelator and inhibitor of metalloproteases. 1,10-Phenanthrine acts as a fungistatic against P. verrucosa (MIC = 0.8 μg/ml) and inhibits zinc-induced P. verrucosa metallo-type peptidase activity in a concentration-dependent manner. It reduces the expression of matrix metalloproteinase (MMP3) during chondrogenic differentiation of human chondrocytes.