(R) -JAK2/STAT3-IN-1
(R) -JAK2/STAT3-IN-1 is a GP130 D1 domain inhibitor with anti-tumor activity. (R) -JAK2/STAT3-IN-1 can inhibit the phosphorylation of JAK2 and STAT3. The affinity of (R) -JAK2/STAT3-IN-1 for GP130 protein is 3.8 μM. (R) -JAK2/STAT3-IN-1 effectively inhibits the viability and migration of tumor cells and promotes apoptosis[1].
Product Specifications
CAS Number
[2485758-49-2]
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/r-jak2-stat3-in-1.html
Smiles
NC(N1[C@H](CC(C2=CC=C(C=C2)C(F)(F)F)=N1)C(C3=C4)=CN(CC5=CC=C(C=C5)OCCN6CCCCCC6)C3=CC=C4Br)=O
Molecular Formula
C34H35BrF3N5O2
Molecular Weight
682.57
References & Citations
[1]Discovery of bazedoxifene analogues targeting glycoprotein 130
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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