Tolmetin (sodium)
Tolmetin sodium is an orally active and potent COX inhibitor with IC50s of 0.35 μM and 0.82 μM human COX-1 and COX-2, respectively. Tolmetin sodium is a non-steroidal anti-inflammatory drug (NSAID) [1][2].
Product Specifications
CAS Number
35711-34-3
UNSPSC
12352005
Hazard Statement
H302
Target
COX
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tolmetin-sodium.html
Solubility
10 mM in DMSO
Smiles
O=C(CC1=CC=C(N1C)C(C2=CC=C(C)C=C2)=O)O[Na]
Molecular Formula
C15H14NNaO3
Molecular Weight
279.27
Precautions
P264-P270-P330-P501
References & Citations
[1]T D Warner, et al. Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis. Proc Natl Acad Sci U S A. 1999 Jun 22;96 (13) :7563-8.|[2]Etcheverry SB, et al. Three new vanadyl (IV) complexes with non-steroidal anti-inflammatory drugs (Ibuprofen, Naproxen and Tolmetin) . Bioactivity on osteoblast-like cells in culture. J Inorg Biochem. 2002 Jan 1;88 (1) :94-100.|[3]DADAŞ, Yakup, et al. Synthesis and anticancer activity of some novel tolmetin thiosemicarbazides. Marmara Pharmaceutical Journal 19 (3) • April 2015
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
COX-1; COX-2
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