PC Mal-NHS carbonate ester
PC Mal-NHS carbonate ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1].
Product Specifications
CAS Number
1408057-91-9
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pc-mal-nhs-carbonate-ester.html
Purity
95.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(ON1C(CCC1=O)=O)OC(C2=CC(OC)=C(OCCCC(NCCN3C(C=CC3=O)=O)=O)C=C2[N+]([O-])=O)C
Molecular Formula
C24H26N4O12
Molecular Weight
562.48
Precautions
H302, H315, H319, H335
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS6381274-01 0.1 mL
HLA-DPA1 (HLASB, HLA Class II Histocompatibility Antigen, DP alpha 1 Chain, DP(W3), DP(W4), HLA-SB alpha Chain, MHC Class II DP3-alpha, MHC Class II DPA1) (MaxLight 750)
Sign In for Pricing
View Details MBS6381274-02 5x 0.1 mL
HLA-DPA1 (HLASB, HLA Class II Histocompatibility Antigen, DP alpha 1 Chain, DP(W3), DP(W4), HLA-SB alpha Chain, MHC Class II DP3-alpha, MHC Class II DPA1) (MaxLight 750)
Sign In for Pricing
View Details 
MBS438870-01 0.02 mg (With BSA & Azide at 0.2mg/mL)
p21WAF1 (Tumor Suppressor Protein) Mouse Monoclonal Antibody
Sign In for Pricing
View Details