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PC Mal-NHS carbonate ester

PC Mal-NHS carbonate ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1].

Product Specifications

CAS Number

1408057-91-9

UNSPSC

12352203

Hazard Statement

H302, H315, H319, H335

Target

ADC Linker

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pc-mal-nhs-carbonate-ester.html

Purity

95.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(ON1C(CCC1=O)=O)OC(C2=CC(OC)=C(OCCCC(NCCN3C(C=CC3=O)=O)=O)C=C2[N+]([O-])=O)C

Molecular Formula

C24H26N4O12

Molecular Weight

562.48

Precautions

H302, H315, H319, H335

References & Citations

[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

ADC Related

Clinical Information

No Development Reported

Isoform

Cleavable Linker

Available Sizes

Frequently Asked Questions

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POLR1C (DNA-directed RNA Polymerases I and III Subunit RPAC1, DNA-directed RNA Polymerase I Subunit C, RNA Polymerases I and III, Subunit AC1, AC40, DNA-directed RNA Polymerases I and III 40kD Polypeptide, RPA40, RPA39, RPC40, POLR1C, POLR1E) discontinued
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POLR1C (DNA-directed RNA Polymerases I and III Subunit RPAC1, DNA-directed RNA Polymerase I Subunit C, RNA Polymerases I and III, Subunit AC1, AC40, DNA-directed RNA Polymerases I and III 40kD Polypeptide, RPA40, RPA39, RPC40, POLR1C, POLR1E) discontinued
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POLR1C (DNA-directed RNA Polymerases I and III Subunit RPAC1, DNA-directed RNA Polymerase I Subunit C, RNA Polymerases I and III, Subunit AC1, AC40, DNA-directed RNA Polymerases I and III 40kD Polypeptide, RPA40, RPA39, RPC40, POLR1C, POLR1E) discontinued

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