RTRD01
RTRD01 is a TDP-43 ligand that binds to TDP-43’s RRM1 and RRM2 domains (Kd=89 uM for TDP-43102–269) . rTRD01 partially disrupts TDP-43’s interaction with the hexanucleotide RNA repeat of the disease-linked c9orf72 gene. rTRD01 can be used for the research of neurodegenerative diseases[1].
Product Specifications
CAS Number
1332175-56-0
UNSPSC
12352005
Target
Amyloid-β
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/rtrd01.html
Purity
99.10
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CN=CC(N2CCCC(CC3=CC=C(C=C3)F)(C2)CO)=N1)N
Molecular Formula
C18H21FN4O2
Molecular Weight
344.38
References & Citations
[1]François-Moutal L, et al. Small Molecule Targeting TDP-43's RNA Recognition Motifs Reduces Locomotor Defects in a Drosophila Model of Amyotrophic Lateral Sclerosis (ALS) . ACS Chem Biol. 2019 Sep 20;14 (9) :2006-2013.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
KN401329 1 Kit
Transmembrane Protein 101 (TMEM101) Human Gene Knockout Kit (CRISPR)
Sign In for Pricing
View Details 
HA723189B 100 µL
Human OX40/TNFRSF4 Recombinant Rabbit monoclonal Antibody
Sign In for Pricing
View Details