RTRD01

RTRD01 is a TDP-43 ligand that binds to TDP-43’s RRM1 and RRM2 domains (Kd=89 uM for TDP-43102–269) . rTRD01 partially disrupts TDP-43’s interaction with the hexanucleotide RNA repeat of the disease-linked c9orf72 gene. rTRD01 can be used for the research of neurodegenerative diseases[1].

Product Specifications

CAS Number

[1332175-56-0]

UNSPSC

12352005

Target

Amyloid-β

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/rtrd01.html

Purity

99.10

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CN=CC(N2CCCC(CC3=CC=C(C=C3)F)(C2)CO)=N1)N

Molecular Formula

C18H21FN4O2

Molecular Weight

344.38

References & Citations

[1]François-Moutal L, et al. Small Molecule Targeting TDP-43's RNA Recognition Motifs Reduces Locomotor Defects in a Drosophila Model of Amyotrophic Lateral Sclerosis (ALS) . ACS Chem Biol. 2019 Sep 20;14 (9) :2006-2013.