LY2857785

LY2857785 is a type I reversible and competitive ATP kinase inhibitor against CDK9 (IC50 11 nM) and other transcription kinases CDK8 (IC50 16 nM), and CDK7 (IC50 246 nM) .

Product Specifications

CAS Number

[1619903-54-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; CDK

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/LY2857785.html

Purity

99.92

Solubility

DMSO : 10 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

CC(C1=C2C=C(C3=NC(N[C@H]4CC[C@H](NC5CCOCC5)CC4)=NC=C3)C=CC2=NN1C)C

Molecular Formula

C26H36N6O

Molecular Weight

448.60

Precautions

H302, H315, H319, H335

References & Citations

[1]Yin T, et al. A novel CDK9 inhibitor shows potent antitumor efficacy in preclinical hematologic tumor models. Mol Cancer Ther. 2014 Jun;13 (6) :1442-56. Mol Cancer Ther. 2014 Jun;13 (6) :1442-56.