Ziv-aflibercept
Ziv-aflibercept is a soluble inhibitor of vascular endothelial growth factor (VEGF) . Ziv-aflibercept is an adaptive variant of Aflibercept (HY-108801), Ziv-aflibercept has a low PH value and high osmotic pressure when compared to Aflibercept. Ziv-aflibercept has potential applications in metastatic colorectal carcinoma and retinal diseases[1][2].
Product Specifications
CAS Number
[1609655-49-3]
UNSPSC
12352203
Target
VEGFR
Type
Inhibitory Antibodies
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ziv-aflibercept.html
Purity
95.00
Solubility
10 mM in DMSO
Smiles
[Ziv-aflibercept]
Molecular Weight
(96.9 kDa)
References & Citations
[1]Malik D, et al. Safety profiles of anti-VEGF drugs: bevacizumab, ranibizumab, aflibercept and ziv-aflibercept on human retinal pigment epithelium cells in culture. Br J Ophthalmol. 2014 Jun;98 Suppl 1 (Suppl 1) :i11-16. |[2]de Oliveira Dias JR, et al. Fusion proteins for treatment of retinal diseases: aflibercept, ziv-aflibercept, and conbercept. Int J Retina Vitreous. 2016 Feb 1;2:3.
Shipping Conditions
Isolate blue ice and the product with bubble pack to avoid direct contact
Storage Conditions
Store at 4°C, do not freeze
Scientific Category
Inhibitory Antibodies
Clinical Information
Launched
Available Sizes
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