SDZ 216-525

SDZ 216-525 is a selective silent antagonist of 5-HT1A receptor[1][2].

Product Specifications

CAS Number

[141533-35-9]

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sdz-216-525.html

Smiles

O=C(C(N1)=CC2=C1C=CC=C2N3CCN(CCCCN(C(C4=C5C=CC=C4)=O)S5(=O)=O)CC3)OC

Molecular Formula

C25H28N4O5S

Molecular Weight

496.58

References & Citations

[1]Boddeke H W G M, et al. Agonist/antagonist interactions with cloned human 5-HT 1A receptors: variations in intrinsic activity studied in transfected HeLa cells[J]. Naunyn-Schmiedeberg's archives of pharmacology, 1992, 345: 257-263.|[2]Sharp T, et al. The novel 5‐HT1A receptor antagonist, SDZ 216–525, decreases 5‐HT release in rat hippocampus in vivo[J]. British journal of pharmacology, 1993, 109 (3) : 699-702.