DEG-77
DEG-77, is a IKZF2 and CK1α targeted molecular glue, with DC50s of 15.3 nM and 10 nM, respectively. DEG-77 possesses suitable pharmacokinetic properties, solubility, and selectivity for in vivo studies (t1/2=8h) . DEG-77 can be used for acute myeloid leukemia (AML) study[1].
Product Specifications
CAS Number
[3032265-06-5]
UNSPSC
12352005
Target
Casein Kinase; Molecular Glues
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PROTAC; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/deg-77.html
Concentration
10mM
Purity
99.03
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
O=C1C2=CC=C(C=C2CN1C3CCC(NC3=O)=O)NC(C4=CC5=C(OC4)C(OC)=CC=C5)=O
Molecular Formula
C24H21N3O6
Molecular Weight
447.44
References & Citations
[1]David K Miyamoto, et al. Design and Development of IKZF2 and CK1α Dual Degraders. J Med Chem. 2023 Dec 28;66 (24) :16953-16979.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CK1
Available Sizes
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