DEG-77
Product Specifications
UNSPSC Description
DEG-77, a IKZF2 and CK1α targeted molecular glue, possesses suitable pharmacokinetic properties, solubility, and selectivity for in vivo studies (t1/2=8h)[1].
Target Antigen
Casein Kinase; Molecular Glues
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;PROTAC;Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/deg-77.html
Solubility
DMSO : 50 mg/mL (ultrasonic;warming;heat to 80°C)
Smiles
O=C1C2=CC=C(C=C2CN1C3CCC(NC3=O)=O)NC(C4=CC5=C(OC4)C(OC)=CC=C5)=O
Molecular Weight
447.44
References & Citations
[1]David K Miyamoto, et al. Design and Development of IKZF2 and CK1α Dual Degraders. J Med Chem. 2023 Dec 28;66(24):16953-16979.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-157334/DEG-77-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-157334/DEG-77-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
3032265-06-5
Available Sizes
Curated Selection
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