L-2-Hydroxyglutaric acid

L-2-Hydroxyglutaric acid is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid can inhibit histone demethylases and hence promote histone methylation[1]. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively[2].

Product Specifications

CAS Number

[13095-48-2]

Product Name Alternative

(S) -2-Hydroxyglutaric acid

UNSPSC

12352211

Hazard Statement

H302, H312, H332

Target

Endogenous Metabolite; Histone Demethylase; Mitochondrial Metabolism

Type

Natural Products

Related Pathways

Epigenetics; Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/L-2-Hydroxyglutaric_acid.html

Concentration

67.52 mM * 1 mL in Ethanol

Purity

95.11

Solubility

10 mM in DMSO

Smiles

O=C(O)[C@@H](O)CCC(O)=O

Molecular Formula

C5H8O5

Molecular Weight

148.11

Precautions

H302, H312, H332

References & Citations

[1]Shim EH, et al. L-2-Hydroxyglutarate: an epigenetic modifier and putative oncometabolite in renal cancer. Cancer Discov. 2014 Nov;4 (11) :1290-8.|[2]da Silva CG, et al. L-2-hydroxyglutaric acid inhibits mitochondrial creatine kinase activity from cerebellum of developing rats. Int J Dev Neurosci. 2003 Jun;21 (4) :217-24.