SDH-IN-12

SDH-IN-12 (compound 9b) is a succinate dehydrogenase inhibitor, which exhibits activity against S. sclerotiorum and C. arachidicola, with EC50s of 0.97 and 2.07 μM, respectively. SDH-IN-12 reveals no significant herbicidal activity against monocotyledonous and dicotyledonous plants[1].

Product Specifications

CAS Number

[3027210-28-9]

UNSPSC

12352005

Target

Fungal; Succinate Dehydrogenase

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/sdh-in-12.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1=C(C2=CC(F)=C(F)C(F)=C2)C=CC=C1)NC(C3=CN(C)N=C3C(F)F)=O

Molecular Formula

C19H13F5N4O2

Molecular Weight

424.32

References & Citations

[1]Sun NB, et al., Novel Pyrazole Acyl (thio) urea Derivatives Containing a Biphenyl Scaffold as Potential Succinate Dehydrogenase Inhibitors: Design, Synthesis, Fungicidal Activity, and SAR. J Agric Food Chem. 2024 Feb 7;72 (5) :2512-2525.