YZL-51N

YZL-51N is a selective SIRT7 inhibitor with IC50 value of 12.71 μM. YZL-51N disrupts SIRT7 enzyme activity by occupying the NAD+ binding pocket, thereby weakening DNA damage repair and inhibiting cancer cell survival. YZL-51N possesses anti-tumor activity and can be used in cancer research[1].

Product Specifications

CAS Number

[3031072-69-9]

UNSPSC

12352005

Target

Sirtuin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/yzl-51n.html

Purity

95.0

Solubility

DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(OC)/C(C1=CC=C(O)C(O)=C1)=C\C(C2=CC=C(O)C(O)=C2)=O

Molecular Formula

C17H14O7

Molecular Weight

330.29

References & Citations

[1]Kang TS, et al. YZL-51N functions as a selective inhibitor of SIRT7 by NAD+ competition to impede DNA damage repair. iScience. 2024 May 16;27 (6) :110014.