SALL2 (C) Antibody, Rabbit Polyclonal

Rabbit polyclonal to SALL2. SALL proteins are C2H2 zinc-finger transcription factors in which the zinc-finger motifs are distributed over the entire protein. They contain glutamine-, proline-and alanine-rich sequences typical of transcriptional activators or repressors. Four members of the human family have been identified, SALL 1-4. Although human SALL-1, -3 and -4 are associated with malformation syndromes, SALL2 is not. Rather, SALL2 is a potential tumour suppressor. The SALL2 gene maps to 14q11.1-13, a region associated with loss of heterozygosity in half of human ovarian cancers. SALL2 is well expressed in ovarian epithelial cells but depleted in ovarian carcinoma cells. Expression of SALL2 in ovarian carcinoma cells inhibits DNA synthesis and colony formation, increases expression of p21WAF1/CIP1 and reduces tumorigenicity.