PRT4165

PRT4165 is a potent inhibitor of polycomb-repressive complex 1 (PRC1) -mediated H2A ubiquitylation.

Product Specifications

CAS Number

[31083-55-3]

Product Name Alternative

NSC600157

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

E1/E2/E3 Enzyme

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/PRT4165.html

Concentration

10mM

Purity

98.0

Smiles

O=C1/C(C(C2=C1C=CC=C2)=O)=C/C3=CC=CN=C3

Molecular Formula

C15H9NO2

Molecular Weight

235.24

Precautions

H315, H319, H320

References & Citations

[1]Ismail IH, et al. A small molecule inhibitor of polycomb repressive complex 1 inhibits ubiquitin signaling at DNA double-strand breaks. J Biol Chem. 2013 Sep 13;288 (37) :26944-54.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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