XCT790
XCT-790 is a potent and selective inverse agonist for ERRα with an IC50 value of 0.37 μM. XCT-790 induces cell death in chemotherapeutic resistant cancer cells. XCT-790 (Compound 12) is inactive against ERRγ and the estrogen receptors ERα and ERβ[1][2].
Product Specifications
CAS Number
725247-18-7
UNSPSC
12352005
Hazard Statement
H302, H413
Target
Autophagy; Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Autophagy; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/XCT790.html
Concentration
10mM
Purity
99.67
Solubility
DMSO : 16.67 mg/mL (ultrasonic)
Smiles
O=C(NC1=NN=C(C(F)(F)F)S1)/C(C#N)=C/C2=CC=C(OCC3=C(C(F)(F)F)C=C(C(F)(F)F)C=C3)C(OC)=C2
Molecular Formula
C23H13F9N4O3S
Molecular Weight
596.42
Precautions
H302, H413
References & Citations
[1]Wu F, et al. Estrogen-related receptor alpha (ERRalpha) inverse agonist XCT-790 induces cell death in chemotherapeutic resistant cancer cells. Chem Biol Interact. 2009 Oct 7;181 (2) :236-42.|[2]Busch BB, et al. Identification of a selective inverse agonist for the orphan nuclear receptor estrogen-related receptor alpha. J Med Chem. 2004 Nov 4;47 (23) :5593-6.|[3]Kokabu T, et al. Antitumor effect of XCT790, an ERRα inverse agonist, on ERα-negative endometrial cancer cells. Cell Oncol (Dordr) . 2019 Apr;42 (2) :223-235.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERRα
Available Sizes
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