XCT790

XCT-790 is a potent and selective inverse agonist for ERRα with an IC50 value of 0.37 μM. XCT-790 induces cell death in chemotherapeutic resistant cancer cells. XCT-790 (Compound 12) is inactive against ERRγ and the estrogen receptors ERα and ERβ[1][2].

Product Specifications

CAS Number

[725247-18-7]

UNSPSC

12352005

Hazard Statement

H302, H413

Target

Autophagy; Estrogen Receptor/ERR

Type

Reference compound

Related Pathways

Autophagy; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/XCT790.html

Concentration

10mM

Purity

99.67

Solubility

DMSO : 16.67 mg/mL (ultrasonic)

Smiles

O=C(NC1=NN=C(C(F)(F)F)S1)/C(C#N)=C/C2=CC=C(OCC3=C(C(F)(F)F)C=C(C(F)(F)F)C=C3)C(OC)=C2

Molecular Formula

C23H13F9N4O3S

Molecular Weight

596.42

Precautions

H302, H413

References & Citations

[1]Wu F, et al. Estrogen-related receptor alpha (ERRalpha) inverse agonist XCT-790 induces cell death in chemotherapeutic resistant cancer cells. Chem Biol Interact. 2009 Oct 7;181 (2) :236-42.|[2]Busch BB, et al. Identification of a selective inverse agonist for the orphan nuclear receptor estrogen-related receptor alpha. J Med Chem. 2004 Nov 4;47 (23) :5593-6.|[3]Kokabu T, et al. Antitumor effect of XCT790, an ERRα inverse agonist, on ERα-negative endometrial cancer cells. Cell Oncol (Dordr) . 2019 Apr;42 (2) :223-235.