Captodiame

Captodiame (Captodiamine) is a 5-HT2c receptor antagonist and sigma-1 and D3 dopamine receptor agonist. Captodiame shows antidepressant effect[1].

Product Specifications

CAS Number

[486-17-9]

Product Name Alternative

Captodiamine

UNSPSC

12352005

Target

5-HT Receptor; Dopamine Receptor; Sigma Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/captodiame.html

Smiles

CCCCSC1=CC=C(C(SCCN(C)C)C2=CC=CC=C2)C=C1

Molecular Formula

C21H29NS2

Molecular Weight

359.59

References & Citations

[1]Ring RM, et al. Captodiamine, a putative antidepressant, enhances hypothalamic BDNF expression in vivo by synergistic 5-HT2c receptor antagonism and sigma-1 receptor agonism. J Psychopharmacol. 2013;27 (10) :930-939.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

5-HT2 Receptor

Curated Selection

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