TFAP2B (N1) Antibody, Rabbit Polyclonal

Rabbit polyclonal to TFAP2B. Transcription factor AP-2-beta (TFAP2B) belongs to the AP-2 family and is a sequence-specific DNAbinding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5-GCCNNNGGC-3 and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia.