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TET2 (N2) Antibody, Rabbit Polyclonal

Rabbit polyclonal to TET2. TET2 is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) . 5-hydroxymethylcytosine may influence chromatin structure and recruit specific factors or may constitute an intermediate component in cytosine demethylation. TET2 plays an important role in myelopoiesis, and defects in TET2 gene have been associated with several myeloproliferative disorders.

Product Specifications

Product Name Alternative

Anti Methylcytosine dioxygenase TET2 antibody, anti KIAA1546 antibody

UniProt

Q4JK59

Reactivity

Mouse

Immunogen

N-terminal region of mouse TET2

Clonality

Polyclonal

Conjugation

Unconjugated

Field of Research

Metabolism Research

Concentration

100 μg/ml BSA

Dilution

WB:1:1000-1:3000

Purity

Affinity purification

Molecular Weight

224

References & Citations

Da Silva, Rodrigo A. et al. Laminar shear stress-provoked cytoskeletal changes are mediated by epigenetic reprogramming of TIMP1 in human primary smooth muscle cells J Cell Physiol, 234, 6382-6396 (2019)

Pubmed id

30238981

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Notes

For research use only.

Applications Notes

WB: The apparent protein size on WB may be different from the calculated M.W. due to modifications.Experiment Notes: Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the N-terminal region of mouse TET2.

Tested Applications

ChIP, IF, IP, WB

Host or Source

Rabbit

Preservative

0.01% NaN3

Frequently Asked Questions

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