OPTN (N) Antibody, Rabbit Polyclonal

Rabbit polyclonal to OPTN. Optineurin (OPTN) plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. OPTN links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. OPTN negatively regulates the induction of IFNB in response to RNA virus infection. Additionally, OPTN plays a neuroprotective role in the eye and optic nerve. OPTN is also probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. OPTN may act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD), and it also may constitute a cellular target for adenovirus E3 14.7, an inhibitor of TNF-alpha functions, thereby affecting cell death.