Nalmefene HCl
Opioid Receptor Antagonist
Product Specifications
Background
An opiod antagonist with a very similar activity profile to naloxone, however, it displays slower onset and longer duration of action (1). It antagonizes the effects of salvinorin (2) (delta-agonist) as well as herkinorin (3) (mu-agonist). Has been used as a therapeutic for treatment of alcohol dependence (4).
CAS Number
58895-64-0
Product Name Alternative
(5α) -17- (Cyclopropylmethyl) -4,5-epoxy-6-methylene-morphinan-3,14-diol, hydrochloride
UNSPSC
41116105
Type
Antagonist
Source
Synthetic
Purity
>98% (HPLC) ; NMR (Conforms)
Weight
0.005
Format
White powder
Solubility
May be dissolved in water (25 mg/ml)
Molecular Formula
C21H25NO3 • HCl
Molecular Weight
375.9
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1.Osborn, M.D., et al. (201) Life Sci. 86:624.
2. Butelman E.R., et al. (2009) J. Pharmacol. Exp. Ther. 328:588.
3.Butelman E.R., et al. (2008) J. Pharmacol. Exp. Ther. 327:154.
4.Soyka M., and Rosner S. (2008) Curr. Drug Abuse Rev. 1:280.
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