Anti-GFRα-3 Antibody

Rabbit Polyclonal Antibody specific to GFR-3 (IN)

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

GDNF receptor α-3, GDNFR-α-3, GFR-α-3

Gene Name

Gfra3

Gene ID

14587

NCBI Gene ID

UniProt

O35118

Accession Number

NP_034410

Cellular Locus

Cell membrane, Lipid-anchor, GPI-anchor

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Peptide corresponding to aa 347- 360 of mouse GFRa-3.

Target Antigen

GDNF family receptor α-3

Target

GFRα-3

Clonality

Polyclonal

Isotype

IgG

Type

Antibody

Applications

ELISA, WB, IHC-P, IF

Field of Research

Neuroscience

Purification Method

Purified by Protein G affinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium which is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Receptor for the glial cell line-derived neurotrophic factor, artemin. Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase (By similarity). {ECO:0000250}.

Additionnal Information

Immunoblotting: use at 1:500-1:1,000 dilution. <br><br>Positive control: Tissue lysates of mouse kidney, liver, or heart.

Storage Conditions

This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.

Specificity

This antibody recognizes human, mouse, and rat GFRalpha-3 (approx. 43 kD).

Formulation

PBS, pH 7.4.

Buffer pH

pH 7.4

Target Background

Members of the glial cell line-derived neurotrophic factor (GDNF) family, including GDNF and neurturin (NTN), play key roles in the control of vertebrate neuronal survivial and differentiation. A new member of the GDNF family was recently identified and designated persephin. Physiological responses to these neurotrophic factors requrie two receptor subunits, the novel glycosylphosphatidylinositol linked protein GFRalpha and Ret receptor tyrosine kinase GFRbeta. Following the identification of GFRalpha-1 and â€“2, another receptor in the GFR family was identified in human and mouse and designated GFRalpha-3. GFRalpha-3 binds persephin. Thus, persephin, GFRalpha-3, and Ret PTK form a complex to transmit the persephin signal and to mediate persephin function.

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