BRD8518

BRD8518 is a PCSK9 inhibitor (EC50=0.23 μM) . BRD8518 lowers blood lipids by upregulating LDLR expression and stimulating LDL uptake. BRD8518 can be used in the study of cardiovascular diseases[1].

Product Specifications

CAS Number

[1565828-01-4]

UNSPSC

12352005

Target

LDLR; PCSK9

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/brd8518.html

Smiles

O=C(NC1=CC=C2C(C(N(C)[C@H]3CC[C@@H](CC(NC4CC(C=CC=C5)=C5C4)=O)O[C@H]3CO2)=O)=C1)C6=CC=C(C(F)(F)F)C=C6

Molecular Formula

C33H32F3N3O5

Molecular Weight

607.62

References & Citations

[1]Xuhui Bao, et al. "Targeting proprotein convertase subtilisin/kexin type 9 (PCSK9) : from bench to bedside." Signal Transduction and Targeted Therapy 9.1 (2024) : 13.