(rac)-Streptonigrin
Product Specifications
CAS Number
1079893-79-0
UNSPSC Description
(rac)-Streptonigrin ((rac)-Bruneomycin) is the racemic form of Streptonigrin. Streptonigrin (HY-124586) is a natural product produced by the actinobacterium Streptomyces flocculus, exhibiting antitumor and antibacterial activities. Streptonigrin can act as a pan-PAD inhibitor, with IC50 values of 48.3 μM, 26.1 μM, 0.43 μM, and 2.5 μM for PAD1, PAD2, PAD3, and PAD4, respectively[1].
Target Antigen
Antibiotic; Protein Arginine Deiminase
Type
Reference compound
Related Pathways
Anti-infection;Epigenetics
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/rac-streptonigrin.html
Smiles
O=C(C1=NC(C(N=C2C(C(N)=C3OC)=O)=CC=C2C3=O)=C(C(C4=CC=C(C(OC)=C4O)OC)=C1C)N)O
Molecular Weight
506.46
References & Citations
[1]Dreyton CJ, et al. Insights into the mechanism of Streptonigrin-induced protein arginine deiminase inactivation. Bioorg Med Chem. 2014 Feb 15;22(4):1362-9.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
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