Demeclocycline

Demeclocycline is an orally active tetracycline antibiotic. Demeclocycline impairs protein synthesis by binding to the 30S ribosomal subunit to inhibit binding of aminoacyl tRNA. Demeclocycline shows anti-bacterial activitise to a wide variety of bacterial infections[1][2].

Product Specifications

CAS Number

[127-33-3]

UNSPSC

12352005

Target

Antibiotic; Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/demeclocycline.html

Purity

98.0

Solubility

DMSO : 25 mg/mL (ultrasonic) |H2O : 40 mg/mL (ultrasonic)

Smiles

O=C(C(C1=O)=C(O)[C@@H](N(C)C)[C@]2([H])C[C@]3([H])[C@H](O)C4=C(C(C3=C(O)[C@@]21O)=O)C(O)=CC=C4Cl)N

Molecular Formula

C21H21ClN2O8

Molecular Weight

464.85

References & Citations

[1]I Chopra, et al. Tetracyclines, molecular and clinical aspects. J Antimicrob Chemother. 1992 Mar;29 (3) :245-77.|[2]D Schnappinger, et al. Tetracyclines: antibiotic action, uptake, and resistance mechanisms. Arch Microbiol. 1996 Jun;165 (6) :359-69.|[3]Marleen L A Kortenoeven, et al. Demeclocycline attenuates hyponatremia by reducing aquaporin-2 expression in the renal inner medulla. Am J Physiol Renal Physiol. 2013 Dec 15;305 (12) :F1705-18.|[4]Susobhan Sarkar, et al. Demeclocycline Reduces the Growth of Human Brain Tumor-Initiating Cells: Direct Activity and Through Monocytes. Front Immunol. 2020 Feb 21;11:272.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

Tetracycline

Citation 01

J Hazard Mater Adv. 2025 Nov 12;20:100939.|J Photoch Photobio A. 2020 May. |Chemosphere. 2019 Jun:225:378-387.|Mol Syst Biol. 2022 Sep;18 (9) :e11081.|Patent. US20230014181.