MTOR inhibitor-24
MTOR inhibitor-24 (comounp 9d) is a mTOR inhibitor, with IC50s of 0.34 nM (mTOR) and 324 nM (PI3K-α) respectively. mTOR inhibitor-24 inhibtis LNCaP cell proliferation (IC50: 180 nM) [1].
Product Specifications
CAS Number
1144075-38-6
UNSPSC
12352005
Target
MTOR; PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mtor-inhibitor-24.html
Smiles
O=C(NCCO)NC1=CC=C(C2=NC3=C(C(N4CC5OC(CC5)C4)=N2)SC=C3)C=C1
Molecular Formula
C21H23N5O3S
Molecular Weight
425.50
References & Citations
[1]Verheijen JC, et al. Discovery of 2-arylthieno[3,2-d]pyrimidines containing 8-oxa-3-azabi-cyclo[3.2.1]octane in the 4-position as potent inhibitors of mTOR with selectivity over PI3K. Bioorg Med Chem Lett. 2010 Jan 1;20 (1) :375-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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