NMB-1
NMB-1 is a conopeptide analogue. NMB-1 selectively inhibits sustained mechanically activated currents in sensory neurons (IC50: 1 μM) . NMB-1 inhibits mechanical pain. NMB-1 can be used for research of hearing and pressure-evoked pain[1][2].
Product Specifications
CAS Number
2843557-76-4
UNSPSC
12352209
Target
Others
Type
Peptides
Related Pathways
Others
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nmb-1.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@H](N)CC1=CC=CC=C1)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N2[C@H]3CCC2)=O)[C@H](CC)C)=O)CC(C)C)=O)CSSC[C@H](NC3=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]4CC5=CC=CC=C5)=O)CC6=CC=CC=C6)=O)CCCCN)=O)CCCCN)=O)CC7=CNC=N7)=O)CC(N)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)=O)CSSC[C@H](NC4=O)C(N)=O)=O)CCCNC(N)=N)=O)CC8=CNC9=CC=CC=C89)=O)CC(N)=O
Molecular Formula
C111H164N36O21S4
Molecular Weight
2466.98
References & Citations
[1]Drew LJ, et al. High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked pain. PLoS One. 2007 Jun 13;2 (6) :e515.|[2]Raouf R, et al. Inhibition of somatosensory mechanotransduction by annexin A6. Sci Signal. 2018 Jun 19;11 (535) :eaao2060.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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