Casdatifan
Casdatifan (AB521) is an orally active HIF-2α (hypoxia-inducible factor 2α) inhibitor. Casdatifan exhibited significant antitumor activity and favorable pharmacokinetics in ccRCC (clear cell renal cell carcinoma) models[1].
Product Specifications
CAS Number
2709069-30-5
Product Name Alternative
AB521
UNSPSC
12352005
Target
HIF/HIF Prolyl-Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/casdatifan.html
Purity
96.37
Smiles
CS(C(C1=C2C[C@@H](F)[C@H]1O)=CC=C2[C@](C[C@H](F)[C@@H]3F)([H])C4=C3C=C(F)C=C4C#N)(=O)=O
Molecular Formula
C21H17F4NO3S
Molecular Weight
439.42
References & Citations
[1]Patrick G Schweickert, et al. Casdatifan (AB521) is a novel and potent allosteric small molecule inhibitor of protumourigenic HIF-2α dependent transcription. Br J Pharmacol. 2025 Sep;182 (17) :4147-4167.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
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