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PROTAC IRAK4 degrader-12

PROTAC IRAK4 degrader-12 is a PROTAC based on Cereblon ligand, inducing a maximum degradation rate of IRAK4 of 108.46% in K562 cells with an IC50 value of 4.87 nM (Structure Note: Pink, IRAK4 inhibitor (HY-168611) ; Blue, E3 (HY-W733885) ; Black, linker (HY-168613) ) [1].

Product Specifications

CAS Number

[2919995-09-6]

UNSPSC

12352211

Target

IRAK; PROTACs

Type

Reference compound

Related Pathways

Immunology/Inflammation; PROTAC

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-irak4-degrader-12.html

Smiles

O=C1CCC(C(N1)=O)C2=NOC3=C2C4=C(C(NC(CN5CCN(CC5)C[C@@H]6CC[C@H](CC6)N7C=C(C(C(F)F)=N7)NC(C8=COC(C9=CC(NCC%10CC%10)=NC=C9)=N8)=O)=O)=CC=C4)C=C3.Cl

Molecular Formula

C46H50ClF2N11O6

Molecular Weight

926.41

References & Citations

[1]Jinxia Ling, et al. Preparation method for naphthoisoxazole compound. WO2024199146A1 2024-10-03.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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