PROTAC IRAK4 degrader-12
Product Specifications
UNSPSC Description
PROTAC IRAK4 degrader-12 is a PROTAC based on Cereblon ligand, inducing a maximum degradation rate of IRAK4 of 108.46% in K562 cells with an IC50 value of 4.87 nM ( Structure Note: Pink, IRAK4 inhibitor (HY-168611); Blue, E3 (HY-W733885); Black, linker (HY-168613))[1].
Target Antigen
IRAK; PROTACs
Type
Reference compound
Related Pathways
Immunology/Inflammation;PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-irak4-degrader-12.html
Smiles
O=C1CCC(C(N1)=O)C2=NOC3=C2C4=C(C(NC(CN5CCN(CC5)C[C@@H]6CC[C@H](CC6)N7C=C(C(C(F)F)=N7)NC(C8=COC(C9=CC(NCC%10CC%10)=NC=C9)=N8)=O)=O)=CC=C4)C=C3.Cl
Molecular Weight
926.41
References & Citations
[1]Jinxia Ling, et al. Preparation method for naphthoisoxazole compound. WO2024199146A1 2024-10-03.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-168586/PROTAC-IRAK4-degrader-12-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-168586/
Clinical Information
No Development Reported
CAS Number
2919995-09-6
Curated Selection
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