Nipecotic acid
Product Specifications
UNSPSC Description
Nipecotic acid ((±)-β-Homoproline) is a potent inhibitor of neuronal and glial-aminobutyric acid (GABA) uptake in vitro. Nipecotic acid can also directly activate GABAA-like chloride channels, with an EC50 of approximately 300?μM[1][2].
Target Antigen
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel;Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nipecotic-acid.html
Purity
98.0
Solubility
DMSO : < 1 mg/mL (ultrasonic)|H2O : 50 mg/mL (ultrasonic)
Smiles
O=C(C1CNCCC1)O
Molecular Weight
129.159
References & Citations
[1]Barrett-Jolley R, et, al. Nipecotic acid directly activates GABA(A)-like ion channels. Br J Pharmacol. 2001 Jul;133(5):673-8.|[2]Dhanawat M, et, al. Design, Synthesis and Enhanced BBB Penetration Studies of L-serine-Tethered Nipecotic Acid-Prodrug. Drug Res (Stuttg). 2021 Feb;71(2):94-103.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-69359/Nipecotic-acid-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-69359/Nipecotic-acid-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
498-95-3
Available Sizes
Curated Selection
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