Nipecotic acid

Nipecotic acid ((±) -β-Homoproline) is a potent inhibitor of neuronal and glial-aminobutyric acid (GABA) uptake in vitro. Nipecotic acid can also directly activate GABAA-like chloride channels, with an EC50 of approximately 300 μM[1][2].

Product Specifications

CAS Number

[498-95-3]

Product Name Alternative

(±) -β-Homoproline; Hexahydronicotinic acid; 3-Carboxypiperidine

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/nipecotic-acid.html

Purity

98.0

Solubility

DMSO : < 1 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

Smiles

O=C(C1CNCCC1)O

Molecular Formula

C6H11NO2

Molecular Weight

129.16

Precautions

H315, H319, H335

References & Citations

[1]Barrett-Jolley R, et, al. Nipecotic acid directly activates GABA (A) -like ion channels. Br J Pharmacol. 2001 Jul;133 (5) :673-8.|[2]Dhanawat M, et, al. Design, Synthesis and Enhanced BBB Penetration Studies of L-serine-Tethered Nipecotic Acid-Prodrug. Drug Res (Stuttg) . 2021 Feb;71 (2) :94-103.