DPP-8/9 probe-1
DPP-8/9 probe-1 (compound 20) is a fluorescent probe targeting Dipeptidyl Peptidase DPP8/9, which can be selectively labeled and visualized in vitro by fluorescence microscopy Active DPP8/9. DPP-8/9 probe-1 contains a nitrobenzoxadiazole (NBD) tag and has high affinity and selectivity for DPP8/9 over related S9 family members (IC50 of 210 nM and 15 nM, respectively) [1].
Product Specifications
CAS Number
[3020859-80-4]
UNSPSC
12171500
Target
Dipeptidyl Peptidase
Type
Dye Reagents
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/dpp-8-9-probe-1.html
Solubility
10 mM in DMSO
Smiles
O=C(CN[C@@]1(C2)C[C@H]3C[C@@](C[C@@H]2C3)(NC(OCCOCCNC4=CC=C([N+]([O-])=O)C5=NON=C54)=O)C1)N(C6)CC7=C6C=CC(F)=C7
Molecular Formula
C31H36FN7O7
Molecular Weight
637.66
References & Citations
[1]Espadinha M, et al. Active site-directed probes targeting dipeptidyl peptidases 8 and 9. Eur J Med Chem. 2024 Apr 15;270:116389.
Shipping Conditions
Room temperature
Scientific Category
Dye Reagents
Clinical Information
No Development Reported
Isoform
DPP-4; DPP-8; DPP-9
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