NBD-2
NBD-2 is an inhibitor of the NEMO-IKKα/β interaction in the NF-κB signaling pathway. NBD-2 specifically inhibits the typical NF-κB signaling pathway in vitro and in vivo, reducing the inflammatory response in lipopolysaccharide (LPS) induced acute lung injury (ALI) . NBD-2 exhibits significant anti-inflammatory activity. NBD-2 can be used to study diseases related to NF-κB signaling pathway, including autoimmune diseases, cancer, etc[1].
Product Specifications
UNSPSC
12352209
Target
NF-κB
Type
Peptides
Related Pathways
NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nbd-2.html
Smiles
O=C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](CSC(C(F)=C1F)=C(F)C(F)=C1C2=C(F)C(F)=C3C(F)=C2F)C(N[C@@H](CC4=CNC5=CC=CC=C45)C(N[C@@H](CS3)C(N[C@@H](CC6=CNC7=CC=CC=C67)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(O)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]([C@H](O)C)N
Molecular Formula
C73H86F8N14O17S2
Molecular Weight
1647.66
References & Citations
[1]Li S, et al. Development of a Decafluorobiphenyl Cyclized Peptide Targeting the NEMO–IKKα/β Interaction that Enhances Cell Penetration and Attenuates Lipopolysaccharide-Induced Acute Lung Injury[J]. Bioconjugate Chemistry, 2024.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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