Ethopropazine (hydrochloride)

Ethopropazine (Isothazine) hydrochloride is a potent and selective BChE inhibitor, a poor AChE inhibitor and a non-selective mAChR and NMDA antagonist. Ethopropazine hydrochloride has anticholinergic, antihistamine, antiadrenergic actions and properties. Ethopropazine hydrochloride alleviates thermal hyperalgesia in a dose dependent manner. Ethopropazine hydrochloride can be used for the research of Parkinson’s disease[1][2][3][4][5].

Product Specifications

CAS Number

[1094-08-2]

Product Name Alternative

Isothazine

UNSPSC

12352005

Hazard Statement

H302

Target

Cholinesterase (ChE) ; iGluR; mAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ethopropazine-hydrochloride.html

Purity

99.32

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CCN(CC)C(C)CN1C2=CC=CC=C2SC3=CC=CC=C13.[H]Cl

Molecular Formula

C19H25ClN2S

Molecular Weight

348.93

Precautions

H302

References & Citations

[1]Giladi N, et al. Toxicity of the specific antimuscarinic agent methoctramine and other non-specific anticholinergic drugs in human neuroblastoma cell lines in vitro. Toxicol In Vitro. 1993 Sep;7 (5) :595-603. |[2]Inazu M, et al. Functional expression of choline transporter-like protein 1 (CTL1) in small cell lung carcinoma cells: a target molecule for lung cancer therapy. Pharmacol Res. 2013 Oct;76:119-31. |[3]Jevtovic-Todorovic V, et al. Anti-parkinsonian agents procyclidine and ethopropazine alleviate thermal hyperalgesia in neuropathic rats. Neuropharmacology. 2003 May;44 (6) :739-48. |[4]Sinko G, et al. Mechanism of stereoselective interaction between butyrylcholinesterase and ethopropazine enantiomers. Biochimie. 2011 Oct;93 (10) :1797-807.|[5]V. Debbeti, et al. Transition Metal Complexes of Ethopropazine: Synthesis and Characterization