Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Quipazine (dimaleate)

Quipazine dimaleate is a 5-HT agonist with a Ki value of 1.4 nM for displaces [3H]GR65630 from 5-HT3R in rat. Quipazine dimaleate shows antiviral activity against SARS-CoV-2 with an EC50 of 31.64 μM. Quipazine dimaleate behaves as a 5-HT3R antagonist in peripheral models. Quipazine dimaleate can be used for neurological disease research[1][2][3][4].

Product Specifications

CAS Number

150323-78-7

UNSPSC

12352005

Hazard Statement

H301

Target

5-HT Receptor; SARS-CoV

Type

Reference compound

Related Pathways

Anti-infection; GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/quipazine-dimaleate.html

Purity

99.96

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(O)/C=C\C(O)=O.O=C(O)/C=C\C(O)=O.C1(N2CCNCC2)=NC3=CC=CC=C3C=C1

Molecular Formula

C21H23N3O8

Molecular Weight

445.42

Precautions

H301

References & Citations

[1]Mok E, et al. Effect of quipazine, a selective 5-HT3 agonist, on dietary self-selection of different macronutrient diets in male and female rats. Appetite. 2000 Jun;34 (3) :313-25.|[2]Günther S, et al. X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease. Science. 2021 May 7;372 (6542) :642-646.|[3]Glennon RA, et al. 5-HT1 and 5-HT2 binding characteristics of some quipazine analogues. J Med Chem. 1986 Nov;29 (11) :2375-80.|[4]Ireland SJ, Tyers MB. Pharmacological characterization of 5-hydroxytryptamine-induced depolarization of the rat isolated vagus nerve. Br J Pharmacol. 1987 Jan;90 (1) :229-38.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

5-HT3 Receptor

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Cebpg sgRNA CRISPR Lentivector (Rat) (Target 3)
K6908204 1.0 µg DNA

Cebpg sgRNA CRISPR Lentivector (Rat) (Target 3)

Sign In for Pricing
View Details
HOMER1 Antibody, FITC conjugated
A39411-100UG 100 µg

HOMER1 Antibody, FITC conjugated

Sign In for Pricing
View Details
SAMD4A Human shRNA Plasmid Kit (Locus ID 23034)
TL301850 1 Kit

SAMD4A Human shRNA Plasmid Kit (Locus ID 23034)

Sign In for Pricing
View Details
TP73 (Tumor Protein p73)
494366 100 µL

TP73 (Tumor Protein p73)

Sign In for Pricing
View Details
Hsa-miR-1273c miRNA Agomir
CMJ0932-01 5 nmol

Hsa-miR-1273c miRNA Agomir

Sign In for Pricing
View Details
Hsa-miR-1273c miRNA Agomir
CMJ0932-02 10 nmol

Hsa-miR-1273c miRNA Agomir

Sign In for Pricing
View Details