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8-Benzylthio-cAMP

8-Benzylthio-cAMP is a derivative of cyclic adenosine monophosphate (cAMP) . 8-Bn-cAMP is a site-selective activator of cAMP-dependent protein kinases. Compared with cyclic adenosine monophosphate, it is more stable to phosphodiesterase (PDE) hydrolysis and has higher membrane permeability. 8-Bn-cAMP can be used to study the role of cAMP in regulating cell proliferation, differentiation and apoptosis[1].

Product Specifications

CAS Number

50655-17-9

UNSPSC

12352005

Target

Apoptosis; PKA

Type

Reference compound

Related Pathways

Apoptosis; Stem Cell/Wnt; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/8-benzylthio-camp.html

Smiles

NC1=C2C(N([C@H]3[C@@H]([C@@]4([H])[C@](COP(O4)(O[Na])=O)([H])O3)O)C(SCC5=CC=CC=C5)=N2)=NC=N1

Molecular Formula

C17H17N5NaO6PS

Molecular Weight

473.38

References & Citations

[1]KATAOKA S, et al. Studies on the Synthesis of Compounds Related to Adenosine 3', 5'-Cyclic Phosphate. V.: Synthesis and Cardiac Effect of N6-Alkyladenosine 3', 5'-Cyclic Phosphates and Their 8-Benzylthio Derivatives[J]. Chemical and pharmaceutical bulletin, 1988, 36 (6) : 2212-2219.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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